Evaluation of Anti diarrhoeal Activities of Sapindus Laurifolia Vahl Fruit Extract in Rats

Diarrhoea may be defined as a situation in which an adult daily stool exceeds 200 g and contains 60–95% water. It is the world's third highest killer disease, contributing substantially to pediatric morbidity and mortality, especially in the malnourished. The present study was undertaken to evaluate the effect of hydro alcoholic extract of Sapindus laurifolia Vahl (HASL) for its anti-diarrhoeal potential against several experimental models of diarrhoea in Albino Wistar rats. The anti-diarrhoeal activity of HASL was evaluated using castor oil-induced diarrhoea and magnesium sulphate-induced diarrhoea in rats. Diphenoxylate was used as standard in castor oil induced diarrhoea and Loperamide was used as standard in magnesium sulphateinduced diarrhoea. The HASL showed significant inhibitor activity against castor oil induced diarrhoea, magnesium sulphate-induced diarrhoea, when tested at dose HASL 200, 400 & 600mg/kg, b.w. p.o. It was observed that HASL (600mg/kg, b.w.) is having more potent anti-diarrhoeal activity than HASL (200, 400mg/kg, b.w.) in these models. The study reveals that the fruit extract of Sapindus laurifolia Vahl showed significant anti-diarrhoeal activity.