Research Journal of Pharmacology and Pharmacodynamics

Obesity is often defined simply as a condition of abnormal or excessive fat accumulation in adipose tissue, to the extent that health may be impaired. The present study was undertaken to evaluate anti-obesity effect of hydro-alcoholic extracts of Echinochloa crusgalli on high fat diet induced obesity in albino rats. Obesity was induced by administration of high fat diet for 4 weeks with normal diet and obtained obese rats were treated with Echinochloa crusgalli in a dose of 200, 400 and 600 mg/kg, b.w. p.o for next 4 weeks. It showed significant decrease in body weights, adipose tissue weight, SGOT and SGPT levels, blood glucose levels, LDL-C, VLDL-C, total cholesterol, triglyceride levels, atherogenic index, and also showed significantincrease in HDL-C levels when compared with high fat diet control.