1Department of Pharmacy, Shri G.S. Institute of Technology and Science, Indore 452003, India
2Department of Analytical Development, Torrent Pharmaceutical Ltd., Ahmedabad, India
*Corresponding Author E-mail: mahaveer2singh@gmail.com
A simple and sensitive reverse phase high performance liquid chromatographic method has been developed for estimation of Carvedilol in pharmaceutical formulation. The quantification was carried out using Inertsil C8 150 mm* 4.6mm, 5μm column in isocratic mode. The mobile was made up of buffer and Acetonitrile in the ratio of 65:35 (v/v). Potassium dihydrogen phosphate was used for preparation of buffer. The detection was carried out at 240nm and linearity was found to be in the range of 2 to 10 μg/ml. The method was duly validated as per ICH guidelines.
RP-HPLC, Carvedilol, pharmaceutical dosage form Acetonitrile
