Design, Development and In Vitro Evaluation of Directly Compressed Sustained Release Matrix Tablet of Famotidine

An attempt has been made in this study to develop sustained release matrix tablet of Famotidine by direct compression method using two different polymers like-Ethylcellulose (EC) and Eudragit L100 (EL100) in combine form at various ratios. Powders were evaluated for angle of repose, loose bulk density and tapped bulk density whereas the prepared tablets were evaluated for weight variation, thickness and diameter, hardness, friability, drug content and in vitro dissolution study. The drug release kinetic was fitted in three different mathematical models like-Zero order, Higuchi and Korsmeyer-Peppas model. The results indicate that all the formulations predominantly follow Higuchi model and showed Fickian Diffusion controlled drug release