Formulation Development and Evaluation of Glibenclamide Microcapsules Using Solvent Evaporation Technique

In the present study, microcapsules containing glibenclamide were prepared by solvent evaporation method and characterized by sieve analysis and scanning electron microscopy. The microcapsules were analyzed for % encapsulation efficiency, physical properties and in-vitro release pattern. Different batches of microcapsules were prepared by altering the drug:polymer ratio. The size of microcapsules were in the range of 180–250 μm they were spherical in shape as evidenced by photo micrographs and scanning electron microscopy. The % drug entrapment was in the range of 58–83% and showed sustained drug release over a period of 12 hour.