Hard Capsules: A Suitable Alternative to Soft Gelatin Capsules for Delivering Liquid Drugs

Liquid filled soft gelatin capsules have been successfully used for delivering a variety of liquid drugs. However, these soft capsules possess certain drawbacks. The important one is the in-house development and manufacturing is difficult and costlier. The filling of liquids into hard gelatin capsules may help to overcome the drawbacks and offer added advantages. In the present study attempts have been made to design and develop liquid filled hard gelatin capsules and to evaluate and compare their suitability for liquid filling with marketed soft gelatin capsules. Thus, the purpose of the study was to know whether hard capsules could act as a suitable alternative to soft capsules for delivering liquid drugs.