Formulation and In-vitro Evaluation of Rapidly Disintegrating Tablets Using Hydrochlorothiazide as a Model Drug

The present study was aimed towards the formulation and invitro evaluation of rapidly disintegrating tablets by direct compression technology using hydrochlorothiazide as a model drug. Fast disintegrating tablet of hydrochlorothiazide was formulated using different concentration (2%, 3%, 4% and 5%) of superdisintegrants like Croscarmellose sodium and Crospovidone. All the batches were prepared by direct compression method using the Cadmach Single punch tablet compression machine using 8 mm flat punch. Disintegration time and drug release were taken as the basis to optimize the rapidly disintegrating tablet. Prepared tablets were evaluated for thickness, hardness, friability, uniformity of weight, disintegration time, wetting time and dissolution study. Crospovidone in the concentration of 4% gives fasted disintegration in 16 sec. and shows 100% drug release within 14 min. is selected as the optimized formulation. Optimized formulation was subjected to stability studies for thirty days which showed stability with regards to release pattern.