1Pranveer Singh Institute of Technology Bhauti, Kalpi Road, Kanpur, India
2Institute of Pharmacy Bundelkhand University, Jhansi-284128 (U.P) India
3Department of Pharmaceutical Sciences, Dr. H.S.Gour University, Sagar-470003 (M.P) India
*Corresponding Author E-mail: raivicte@rediffmail.com
Reverse micelle system bearing insulin was developed for controlled and prolonged release of drug through ocular route. The system was prepared by using cetyl tri-ammonium bromide and span-60 separately with organic solvent isopropyl myristate. The effect of temperature and polarity on the system was studied by measuring the drug content. In-vitro drug release study was carried out by using a Frang diffusion cell and artificial tear solution as diffusion medium. It was observed that the micellar systems exhibited prolonged and controlled release of insulin.
Reverse micelles, Insulin, Ocular delivery
