Development and In-vitro Evaluation of Mucoadhesive Buccal Tablets of Domperidone

Mucoadhesive buccal tablet of Domperidone were fabricated with objective of avoiding first pass metabolism and to improve its bioavailability with reduction in dosing frequency. The mucoadhesive polymers used in the formulations were Carbopol 934P, Methocel K4M, MethocelE15LV and Chitosan. Tablets were prepared by direct compression method using polymer in different ratios. The formulations were characterized for swelling index, in-vitro bioadhesion strength and in-vitro release studies. The best mucoadhesive performance and in- vitro drug release profile were exhibited by the tablet containing chitosan and Methocel K4M in ratio of 1:1. It was observed that the optimized formulation follows Hixson Crowel release kinetics.