Research Journal of Pharmacy and Technology

Nimesulide crystals recrystallized from methanol, ethanol and DMSO solutions under different conditions (cooling rate or crystallization temperature, ultrasonication techniques). Scanning electron microscopy used to study crystal habit and X-ray powder diffractometry, FT-IR spectrometry and differential scanning calorimetry were used to investigate the physical characteristics of the crystals. Recrystallization produces needle shape crystals with methanol and ethanol and irregular rod shape with DMSO. Size of crystals form at cool and heat temperature are small. X-ray diffraction spectra and differential scanning calorimetry studies show polymorphic change. Ultrasound can induce nucleation in conditions where spontaneous primary nucleation cannot occur. This phenomenon results in a reduction in particle size but no effect on crystal habit.