The purpose of the study was to improve the Physicochemical properties of Mesalamine like solubility, dissolution properties and stability of a poorly water-soluble drug like Mesalamine by forming dispersions with polyvinylpyrrolidone (PVP), Polyethylene Glycol (PEG) and β- Cyclodextrine as water-soluble carriers. The solid dispersion of Mesalamine by kneading method were prepared using 1:2 and 1:3 ratios of drug to polymers polyvinylpyrrolidone (PVP), Polyethylene Glycol (PEG) and β-Cyclodextrin. The saturation Solubility study was carried out by using flask shaker method at room temperature. Dissolution study was conducted in 0.1N HCl at 37°C ± 0.5°C using USP type II (paddle) type dissolution apparatus. The prepared dispersion showed marked increase the saturation solubility and dissolution rate of Mesalamine than that of drug alone. The dispersion with β Cyclodextrine (1:3) showed faster dissolution rate as compared to the other prepared dispersions. Characterization of Mesalamine solid dispersion was performed by Fourier Transform Infrared (FTIR) and X-ray powder diffractometry study. The stability studies performed on the mesalamine pure drug and optimized solid dispersion with β- Cyclodextrins (1:3) in accelerated condition upto six months. The stability study reveals no significant variation in in-vitro dissolution study of optimized solid dispersion β-Cyclodextrins (1:3) up to six month comparative to pure mesalamine drug.
Solid dispersion, water-soluble carriers, Mesalamine, β Cyclodextrine
