Formulation and Evaluation of Sustained Release System for an Effective Management of Motion Sickness

Cinnarizine is the most effective drug for management of motion sickness which is selective calcium antagonist inhibiting the influx of calcium itracellularly. Cinnarizine pellets were prepared by powder-layering technique, using Cinnarizine as active ingredient and Eudragit RS-100, Eudragit RL-100, Ethyl cellulose as coating agent, with propylene glycol as plasticizers and PVPK-30 as binder. Drug content was estimated spectrophotometrically at 254 nm. The prepared pellets were further evaluated for surface texture by scanning electron microscopy, uniformity of diameter, thickness and weight, invitro drug release pattern and short-term stability. Pellets coated with 10% Eudragit RS-100 showed promising results releasing more than 95% of drug up to 12 hours. This study concluded that the powder layering technique can be used for designing sustained release drug delivery systems providing drug release over a period of 12 hours.