Formulation and In vitro Characterization of Ketoconazole Liposomal Gel for Transdermal Delivery

Liposomes are used because have many of the requirements for good drug delivery systems as they are relatively non-toxic and bio-degradable. And they help the ketoconazole to pass through the skin layers. Phosphatidyl choline and cholesterol were taken in different concentration. Liposomes are prepared by using thin film hydration technique. Gel containing carbopol 934 was prepared and characterization tests were performed for liposomal dispersion and liposomal gel. Liposomal gels were prepared with 1%, 1.5% and 2% carbopol gels which gave the clear idea for the efficient concentration of carbopol in topical gel.