Design, Synthesis and Characterization of 2-pyridone Derivatives as C-Jun N-terminal Kinases (JNKs) Signaling Pathway Inhibitors

A new series of 2-pyridone derivatives (A1-A6) were synthesized by various substitution and their structures were confirmed by spectral and elemental analyses. The cytotoxic activities of the newly synthesized compounds were docked against JNKs (2WAJ Transferase). JNKs pathway regulates various physiological processes including inflammatory responses, cell differentiation, cell proliferation, cell death, cell survival and expression of proteins. The molecular docking study was used for confirming their interaction with c-Jun N-terminal kinases (JNKs). Through in silico molecular docking study, the result showed that all synthesized derivatives (A1-A6) have low binding energy (Table 1) and have good affinity toward their active pocket thus the synthesized derivatives were considered as good JNKs inhibitors. This will help to inhibit the outgrowth of cell and can be act as good anti cancer agents.