Efficacy of Cox-2 inhibitors in the Clinical Management of TMJ Arthritis: A Review

In the clinical management of arthritis, the choice of nonsteroidal anti-inflammatory drug (NSAID) remains confusing and controversial. The main objective of this review is to addresses the main arguments for the pharmacological and clinical use of COX-2 inhibitors for the clinical management of arthritis. This review concluded that, COX-2 inhibitors are effective and are associated with increased risk of GI, renal, and CV, adverse effects. Complete understanding of the patient's co-morbid conditions and concomitant medications, coupled with precise monitoring during the treatment, may help to decrease the threat of adverse effects induced by selective COX-2 inhibitors.