Synthesis and biological evaluation of novel imidazolinone derivatives

A new series of Oxazolones (2a-j) were prepared by reacting substituted aromatic aldehydes with N-acetylglycine in presence of anhydrous sodium acetate and acetic anhydride as the solvent medium. The respective Oxazolones (2a-j) were then treated with 4-Amino-1,2,4-triazole (1) in glacial acetic acid medium to yield the title compounds Imidazolinones (3a-j). All the newly synthesized compounds were evaluated for their In -Vitro antibacterial and antifungal activities. The new compounds were assigned on the basis of ¹H-NMR, IR, Mass spectral data and elemental analysis.