Research Journal of Pharmacy and Technology

SCOPUS
  • Year: 2017
  • Volume: 10
  • Issue: 6

Synthesis and biological evaluation of novel imidazolinone derivatives

  • Author:
  • B. C. Revanasiddappa, M. Vijay Kumar, Prashanth Nayak, Ajmal Roshan Ali, Jasmine Kalsi
  • Total Page Count: 4
  • Page Number: 1726 to 1729

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte University, Paneer, Deralakatte, Mangalore-575 018, Karnataka, India

*Corresponding Author E-mail: evergreen_revan@rediffmail.com

Online published on 22 September, 2017.

Abstract

A new series of Oxazolones (2a-j) were prepared by reacting substituted aromatic aldehydes with N-acetylglycine in presence of anhydrous sodium acetate and acetic anhydride as the solvent medium. The respective Oxazolones (2a-j) were then treated with 4-Amino-1,2,4-triazole (1) in glacial acetic acid medium to yield the title compounds Imidazolinones (3a-j). All the newly synthesized compounds were evaluated for their In -Vitro antibacterial and antifungal activities. The new compounds were assigned on the basis of 1H-NMR, IR, Mass spectral data and elemental analysis.

Keywords

Oxazolones, Imidazolinones, N-acetylglycine, Antibacterial, Antifungal