Synthesis and Antimicrobial Evaluation of Some New Isoxazoline Incorporated Pyrrole Derivatives

A series of novel substituted 3-(2, 4-dimethyl-1H-pyrrol-3-yl)-5-phenyl-4, 5-dihydroisoxazole (AFI1-AFI6) have been synthesized upon reaction with 3-(2, 4-dimethyl-1H-pyrrol-3-yl)-1-phenyl-prop-2-en-1-one using hydroxylamine hydrochloride as cyclising agent in alcohol medium. 3-(2, 4-dimethyl-1H-pyrrol-3-yl)-1-phenylprop-2-en-1-one were synthesized by condensing 3-acetyl-2, 4-dimethyl pyrrole with different substituted benzaldehyde in presence of ethanolic 20% KOH. The structures of the final synthesized compounds were characterized by IR and ¹H NMR spectra. The final synthesized compounds were screened for their in vitro antibacterial activity by cup plate method.