Role of Salivary Interleukin 1 in Chronic Periodontitis: A Review

Periodontal diseases are a group of inflammatory disorders that are caused by pathogenic bacteria in the sub gingival biofilm leading to association with impaired host immune response and connective tissue breakdown. There has been substantial evidence for the central role played by cytokine networks in periodontal diseases of which interleukin 1 has a significant role in periodontal disease pathogenesis. Studies of the immunopathogenesis of periodontitis and analysis of mediators in saliva have allowed the identification of many potentially useful biomarkers.[1] This current review focuses on the role of salivary interleukin 1 level in chronic periodontitis