Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2018
  • Volume: 11
  • Issue: 10

Synergistic Molecular Effect of BDNF, ApoE and MTHFR in inducing Depression in Alzheimer's Disease

  • Author:
  • Zainab Mir1, Rosliza2, Behroz Naeem1, Ilyas Muhammad Nadeem2, Nordin Bin Simbak2, Zubaidi ALA2, Tengku Mohammad Ariff3, M.R Khalili4, Mohammad Amjad Kamal5, Atif Amin Baig2,
  • Total Page Count: 7
  • Page Number: 4317 to 4323

1Atta ur Rahman School of Applied Biosciences, National University of Sciences and Technology (NUST), Islamabad, Pakistan

2Faculty of Medicine, Universiti Sultan Zainal Abidin

3iCode-Universiti Sultan Zainal Abidin

4Faculty of Health Sciences, Univeristi Sultan Zainal Abidin

5King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia

*Corresponding Author E-mail: atifamin@unisza.edu.my

Online published on 20 December, 2018.

Abstract

Alzheimer's disease is genetically and pathophysiologically linked to depression. Various studies have been formulated on AD patients with depression and AD patients without depression. Genes like BDNF, ApoE and MTHFR have a significant role in depressed individuals causing the development of Alzheimer's disease. The frequency of each gene marks the onset of Alzheimer's disease. Single Nucleotide Polymorphisms in each specific gene show the increased risks of developing Alzheimer's disease in depressed individuals. Amyloid Senile plaques and neurofibrillary tangles are caused more often in a depressed individual leading to AD. Development of antidepressants may lead to the correction and diminishing of AD in depressed individuals.

Keywords

Alzheimer's Disease, Depression, BDNF gene, ApoE gene, MTHFR gene, Antidepressants