Research Journal of Pharmacy and Technology

Diabetes has been increasing at an alarming rate around the world, and experts have relied on remedies from the utilization of ancient drugs that are essentially derived from plants.

The present study aimed to evaluate the antidiabetic potential of Ammania baccifera Linn leaf extracts on streptozotocin induced diabetic rats.

Diabetes was induced in male albino wistar rats by single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg b.w.). The diabetic rats were administered orally with Ammania baccifera Linn leaf methanolic extract and isolated fraction (AB) at the dose of 250, 500mg/kg b.w. and 25, 50mg/kg b.w. and glibenclamide (600μg/kg b.w.) as standard by oral route for 45 days.

Methanolic extracts of Ammania baccifera Linn leaf, its isolated fraction AB and glibenclamide treated diabetic rats showed moderate reduction in blood glucose and glycosylated hemoglobin levels; in addition, plasma insulin and hemoglobin levels were elevated. Results of AB, Methanolic extract of Ammania baccifera Linn leaf were comparable to the standard drug glibenclamide (600μg/kg b.w).

The present findings support the usage of the plant extracts for the treatment of diabetes and isolated fraction AB exhibited anti-hyperglycemic activity when compared with standard hypoglycemic agent.