Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur-522 034, Andhra Pradesh, India
*Corresponding Author E-mail: lakshmikakunuri95@gmail.com
Online published on 30 January, 2019.
The aim of this study was to identify the potential of Terminalia chebula as a protective and therapeutic agent against Alzheimer's disease.
The learning and memory enhancing activity of Terminalia chebula fruit extracts were investigated in rats by using the ethanol-induced cognitive impairment and diazepam induced amnesia and its effects on learning and memory were examined by using Morris water maze (MWM) test.
All the groups showed significantly (P value is<0.01 and <0.05) decrease transfer latency at all periods as compared to ethanol and diazepam inducing group. Therefore Fruit extracts of Terminalia chebula exhibited significant learning and memory activity in Alzheimer's disease.
The present study suggests Terminalia chebula that modulate the oxidative stress and be involved in the protective effect against oxidative damage and neurodegenerative diseases in rat.
Ethanol, diazepam, Morris water maze, learning and memory activity, Alzheimer's disease
