Research Journal of Pharmacy and Technology

A series of new substituted coumarinyl schiff base (AJS1-AJS6) have been synthesized by condensing substituted 3-acetyl coumarin and substituted aniline in alcohol medium. The intermediate 3-acetyl coumarin were synthesized by Knoevenagel reaction between substituted salicylaldehyde and ethylacetoacetate in presence of piperidine as catalyst. The structures of the final synthesized compounds were characterized by IR, mass and ¹H NMR spectra. The synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa by tube dilution method. Most of the compounds exhibited promising antibacterial activity compared to the standard drug ciprofloxacin.