Department of Pharmacology, Department of Pharmacy Practice, J.K.K Nattraja College of Pharmacy, Komarapalayam, Tamilnadu, India
Pharmacogenetic polymorphism results from the mutations in a Cytochrome P450 (CYP) gene leading to functional alterations, such as increased or decreased activity and occurs at a frequency of at least one percent in a population. At present clinical situation drug clearance and inter-individual variation in drug response is a usual and complex problem. In this clinical review there is a fast update on pharmacogenetics and genetic polymorphism of CYP enzymes in Indian population.
CYP 450, Pharmacogenetics, Allele, polymorphism
