1Dept. of Pharmaceutics, L.D.E.A's SSM College of Pharmacy, BLDE University Campus, Bijapur-586 103, Karnataka, India
2Dept. of Quality Assurance, B.L.D.E.A's SSM College of Pharmacy, BLDE University Campus, Bijapur-586 103, Karnataka, India
*Corresponding Author E-mail: drccpatil@gmail.com
Online published on 12 June, 2018.
The tablets were prepared by wet granulation method using a combination of Mucoadhesive polymers like Chitosan, Ethyl Cellulose, HPMC and Sodium Alginate in different ratios. Buccal tablets were evaluated by different methods for parameters such as thickness, hardness, in-vitro drug release, ex-vivo drug permeation, etc. The tablets were evaluated for in-vitro release in pH 6.8 phosphate buffer for 12 hr. In order to determine the mode of release, the data was subjected to Zero order, first order, Higuchi and Peppas diffusion model. Sodium Alginate showed maximum mucoadhesion and required maximum force for detachment; the force required for detachment was directly proportional to its content. IR spectroscopic studies indicated that there are no drugexcipient interactions. The prepared buccal tablets of ODH could stay in the buccal for a longer period of time.
Mucoadhesive buccal tablet, Sodium Alginate, HPMC K4M, Chitosan, EC, Mucoadhesive strength, ODH, ex-vivo drug permeation
