A Comprehensive Review on the Role of Tau Proteins in Alzheimer's Pathology

Tau proteins are the one of the most important causes of neurological diseases like Alzheimer's disease (AD). Tau proteins are the stabilized form of microtubule associated protein (MAP) of a normal motor neuron. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are found mostly in neurons compared to non-neuronal cells. One of the tau's main functions is to modulate the stability of axonal microtubules. Neurofibrillary tangles are obtained by hyperphosphorylation of a microtubule associated protein. This article deals with the role of Tau proteins and the methods in which they lead to AD