Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2018
  • Volume: 11
  • Issue: 2

A Comprehensive Review on the Role of Tau Proteins in Alzheimer's Pathology

  • Author:
  • M. Vijey Aanandhi1,, A. Niventhi2, T. Rujaswini2, C.N Hemalatha3, D. Praveen4
  • Total Page Count: 3
  • Page Number: 788 to 790

1Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, (VISTAS) Vels University, Chennai, India

2Department of Pharmacy Practice, School of Pharmaceutical Sciences, (VISTAS) Vels University, Chennai, India

3Research Scholar, Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, (VISTAS) Vels University, Chennai, India

4Research Scholar, School of Pharmaceutical Sciences, (VISTAS) Vels University, Chennai, India

*Corresponding Author E-mail: hodpchemistry@velsuniv.ac.in

Online published on 12 June, 2018.

Abstract

Tau proteins are the one of the most important causes of neurological diseases like Alzheimer's disease (AD). Tau proteins are the stabilized form of microtubule associated protein (MAP) of a normal motor neuron. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are found mostly in neurons compared to non-neuronal cells. One of the tau's main functions is to modulate the stability of axonal microtubules. Neurofibrillary tangles are obtained by hyperphosphorylation of a microtubule associated protein. This article deals with the role of Tau proteins and the methods in which they lead to AD

Keywords

Tau Proteins, Alzheimer's Disease, Tauopathy