Design and Synthesis of Cytarabine new Derivatives as a Possible an Imine Prod rugs with Potential to improve Therapeutic Criteria

Anti metabolite cytarabine is fantastic molecule posses both of most important therapeutic action anti neoplastic and anti viralagent. Today the both of anti cancer and anti viral agent sharing the same therapeutic problems which limit their therapeutic pharmacological biological action which are (the resistance and the cytotoxicity and poor pharmacokinetics parameters). In our project we do the pharmaceutical chemical modifications on the cytarabine as nucleus and targeting amino functionality to design and synthesis the number of new derivatives in light of an pharmaceutical amino group prodrug modification strategies an imine formation to improve therapeutic action (antineoplastic and antiviral action), expected to explore new biological actionand to minimized the emergent resistance, cytotoxicity and expected to improve kinetics of cytarabine.