Jaya College of Paramedical Sciences, Thiruninrvur, Chennai, India
*Corresponding Author E-mail: swetha21112000@gmail.com
Online published on 21 August, 2018.
Worldwide epidemiological rate of psychiatric disorders has been on an increased count among which Depression stands more common than others. Research under this sector is always a choice of interest which is on progress.
The present study is carried out to study the antidepressant activity with aqueous extract of Rosa centifolia.
The extract was primarily subjected for preliminary phytochemical investigation and for Maximum Tolerance Dose (MTD). Antidepressant activity was evaluated in various animal models like Swiss Albino, Mice etc with whom Tail suspension test, Acto-photometer were performed.
The aqueous extract of Rosa centifoliawas positively identified with carbohydrates, tannins, proteins, amino acids, alkaloids, flavonoids, flavanone, glycosides and phenolic compounds. The extract was subjected for maximum tolerance dose upto the dose level of 2000mg/kg has not produced any mortality.
The extract of Rosa centifoliashowed significant antidepressant activity at high dose (100 mg/kg) in Tail suspension test, Acto-photometer. The extract didn't antagonize the hypothermia induced by apomorphine.
Rosa centifolia, petroleum ether extract, Swiss albino mice, Acto photometer, fluoxetine
