1Military Medical Academy N.A.S.M. Kirov, Ministry of Defense of Russian Federation, St. Petersburg
2Research Institute of Oncology named after N.N. Petrov, Ministry of Healthcare of Russian Federation, St. Petersburg
3Russian Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg
4St. Petersburg State Pediatric Medical University, Ministry of Healthcare of Russian Federation, St. Petersburg
5Scientific Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov, Ministry of Healthcare of Russian Federation, Moscow
*Corresponding Author E-mail: rglushakov@yahoo.com
Online published on 24 August, 2018.
Our study examined the effect of induced hypo-and hyperthyroidism on ovarian cancer (OC). The intraperitoneal xenograft model of OCperformed the standard technique. Using propylthiouracil(2, 0 mg per 100 g of animal weight once a day) and L-thyroxine(200 μg per 100 g of animal weight once a day)we found that altered thyroid status significantly influenced the ovary tumor xenografts development. The median survival life expectancy was 9, 6 and 17, 6 daysin the euthyroid control group and the hypothyroid group, respectively (p = 0.02). Induced hypothyroidismleads to thelifetime increase of rats with intraperiton ealxenograft of OC by 83.3%. It was shown that hyporthyroidism was associated with the aggressiveness decrease of OC. Ourevidence confirms previous clinical and epidemiological data. Thyroid status can be anindepending prognostic factor for patients with OC, as well as induced hypotyroidism opens new opportunities for the palliative treatment of OC.
Thyroid hormones, hypothyroidism, ovarian cancer, xenograft, rat
