Synthesis and antimicrobial evaluation of some novel pyrazoline incorporated pyrrole derivatives

The synthesis and antimicrobial evaluation of some novel pyrazoline incorporated pyrrole derivatives has been presented. In this particular presentation novel substituted pyrazoline incorporated pyrrole derivatives (PKS3a-PKS3e) were synthesized by simple condensation reaction between different substituted aldehydes and 3 acetyl 2, 4-dimethyl pyrrole in presence of a strong ethanolic base to yield the pyrrolechalcones. The final synthesized pyrazolincompounds is prepared by the cyclization of pyrrolylchalcones with hydrazine hydratein presence of ethanol. The structures of the final synthesized compounds were characterized by IR, Mass and ¹H NMR spectra. The synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosaby cup plate method. Most of the compounds exhibited promising antibacterial activity.