Response design optimized polymeric nanoparticles of etoposide for improved oral bioavailability in albino rats

Etoposide polymeric nanoparticleswas prepared in order to improve oral bioavailability. Etoposide polymeric nanoparticles was prepared by nanoprecipitation method using Eudragit EPO and Pluronic F-68. The aim of the present investigation was to compare pharmacokinetic profile (bioavailability) of etoposidepolymeric nanoparticles with standard reference. The pure etoposide, etoposidepolymeric nanoparticles and marketed Etoposide formulation were subjected to pharmacokinetic (bioavailability) studies using albino rats as animal model. Several pharmacokinetic parameters like Cmax, Tmax, AUC0→8, Ke, and t1/2 were determined for each group for comparison. The bioavailability of etoposide from pure form, marketed formulation and polymeric nanoparticles was assessed in albino rats at a dose of 9 mg/kg. As compared to the pure etoposide, the absorption of etoposide from polymeric nanoparticles and marketed formulation resulted in 1.23and 1.19 fold increases in bioavailability. The results of the studies indicated that the polymeric nanoparticles approachcan beuseful forimproving theoral bioavailability of etoposide.