New Azomethine-Azo heterocyclic ligands via cyclization of ester

Cyclization reaction has been used to preparation of series heterocyclic azo-azomethine ligands through many steps, the first step: esterification of carboxylic terminal, then cyclization of ester with thiosemicarbazide, followed by second step which involved azotation of amino group of thiadiazole, the third step was reacted with di carbonyl compound, the last step involved cyclization with compounds containing di nucleophile groups to yield series azo heterocyclic-azomethine ligands. The resulting ligands were investigated bymany techniques like (¹H NMR, FT.IR and UV-Visible spectra) with biological test.