Synthesis, Characterization and Biological Evaluation of some Novel 1, 3 Oxazepine derivatives from Vanillin Schiff's Bases

A series of Schiff's bases and their novel derivatives (Oxazepines) have been synthesized, 4-hydroxy-3methoxy benzaldehyde (vanillin) was condensed with different amines to produce the Schiff's bases in the presence of glacial acetic acid as a catalyst or KOH, novel five 1, 3-oxazepine derivatives have been synthesized through reaction of Schiff's bases with succinic anhydride and maleic anhydride using acidic catalyst. The identification was performed using, FT-IR and¹H-NMRspectroscopies. The synthesized1, 3-oxazepine derivatives were biologically screened against gram positive (Staphylococcus aureus) and gram negative bacteria (Escherichia coli). The Results was showed excellent to moderate anti-bacterial activity.