Research Journal of Pharmacy and Technology

Siddha system of medicine enunciates the usage of herbs and herbal formulations since time immemorial. The advancement in the application of ethno-medicine has been increased globally. The treatment approach in Siddha methodology primarily commences with the administration of “Kudineer” i.e. decoction as a first line of treatment for many diseases. Neermulli Kudineer (NMK) is one such polyherbal decoction enumerated in Siddha medical literatures for various ailments. The usage of Neermulli Kudineer is prevalent among the traditional Siddha clinicians in the treatment of diseases such as oedema, urolithiasis, anuria, dysuria, urinary tract infections, oliguria, ascites, inflammation, obesity, renal hypertension and even in the management of certain infertility cases. Thus Neermulli Kudineer has gained its iconic significance as a potent diuretic in Siddha system of medicine. Diuretics in general, play a pivotal role in renal diseases, cardiovascular diseases and liver diseases. As NMK is a natural herbal diuretic in Siddha medicine, it may overcome the adverse effects of conventional diuretics. The current review is aimed to substantiate the traditional efficacy of ingredients of NMK through Siddha literatures and various scientific literatures. The pharmacological review of the ingredients of this decoction revealed their excellency in antiurolithiatic, diuretic, hepatoprotective, nephroprotective, hematinic, anti-inflammatory, lithotriptic, analgesic, antioxidant, antimicrobial, immunomodulatory, antihyperglycemic and lipid lowering activities. Hence the traditional use of Neermulli Kudineer is validated with available literatures.