Research Journal of Pharmacy and Technology

Ethanolic extract from Rhizophora mucronata poir (Rhizophoraceae) leaves was investigated for its antihyperhomocysteinemic and procoagulant factors lowering potential in methionine-induced hyperhomocysteinemia rats. Hyperhomocysteinemia was induced by methionine (1g/kg, p.o., 30days) through drinking water in male albino rats. A significant (p<0.01) increase in Homocysteine, Lactate dehydrogenase (LDH) and procoagulant levels with a concomitant decrease in Thrombin, Prothrombin and APTT times in serum. Were observed in methionine control rats compared with normal healthy control rats. Furthermore, ethanolic extract of Rhizophora mucronata poir (200 and 400mg/kg, p.o., 30days) treatment in both the doses significantly reversed all the above-mentioned parameters compared with methionine control rats. The results of test drug were comparable with Ascorbic acid (100mg/kg, p.o.) which is a potent antioxidant and has the potential to lower the homocysteien levels in the blood. The results indicated that ethanolic extract of Rhizophora mucronata poir has significant antihyperhomocysteinemic and procoagulant factors lowering potential in hyperhomocysteinemic rats.