Stability indicating RP-UPLC method for the simultaneous determination of Atorvastatin and Amlodipine

Amlodipine is a calcium channel blocker. Atorvastatin is used for lowering the cholesterol. A new stability indicating liquid chromatographic method (RP-UPLC) has been proposed for the simultaneous estimation of Atorvastatin and Atorvastatin. Acquity UPLC HSS C18 column was used for the chromatographic study and a mobile phase mixture consisting of 0.1% Formic acid: Acetonitrile: Methanol (0.1:45: 55, v/v)/0.3/220 (Flow rate: 0.3 mL/min) (PDA detector 220 nm) was used for the elution of these two drugs. Stress degradation studies were performed and the method was validated as per ICH guidelines.