Molecular docking, synthesis, α-amylase inhibition, urease inhibition and antioxidant evaluation of 4-hydroxy-3-methoxy benzoic acid derivatives
Abstract
Different derivatives of 4-hydroxy-3-methoxy benzoic acid were synthesized and evaluated for their antioxidant, α-amylase inhibition and urease inhibition ability. Antioxidant evaluation was performed by DPPH radical scavenging assay and the results revealed that compounds 8, 10 and 13 as most active antioxidant agent with IC50 values of 43.09 μg/ml, 44.59 μg/ml and 43.43 μg/ml respectively. α-Amylase inhibition study was performed using diastase by colorimetric method. Compound 9 showed maximum inhibition with IC50 value of 33.26 μg/ml. Compound 4 was found to possess maximum urease inhibition ability with IC50 value of 35.82 μg/ml. Molecular docking study was performed using autodock software.
Keywords
Antioxidant, α-amylase inhibition, urease inhibition, molecular docking study, SAR of 4hydroxy-3-methoxy benzoic acid derivatives
