Research Journal of Pharmacy and Technology

SCOPUS
  • Year: 2019
  • Volume: 12
  • Issue: 12

Study of Inhibition of Methanol Extract of Laban Leaf (Vitex Pinnata) against Sreptococcus mutans with Microdilution

  • Author:
  • Cut Aja Nuraskin1,2,, Marlina3, Rinaldi Idroes3,4, Cut Soraya5, Djufri6
  • Total Page Count: 4
  • Page Number: 6037 to 6040

1Graduate School of Mathematics and Applied Sciences, Universitas Syiah Kuala, Kopelma Darussalam, Banda Aceh, 23111, Indonesia

2Poltekkes Kemenkes Aceh, Jl. Soekarno Hatta, Tingkeum, Darul Imarah, Lheu Blang, Banda Aceh, Aceh Besar District, Aceh, 23231, Indonesia

3Chemistry Department Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Kopelma Darussalam, Banda Aceh, 23111, Indonesia

4Pharmacy Department Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Kopelma Darussalam, Banda Aceh, 23111, Indonesia

5Conservative Dentistry Department Faculty of Dentistry, Universitas Syiah Kuala, Kopelma Darussalam, Banda Aceh, 23111, Indonesia

6Biology Education Department Faculty of Teacher Training and Education, Universitas Syiah Kuala, Kopelma Darussalam, Banda Aceh, 23111, Indonesia

*Corresponding Author E-mail: cutaja82@yahoo.co.id

Online published on 24 February, 2020.

Abstract

Laban (Vitex pinnata) is one of the plants found at the Seulawah's geothermic area, namely ie seu um, which has been widely used as traditional medicine by the Acehnese. Laban contains alkaloids, steroids, terpenoids, saponins, flavonoids, and phenolics/tannins. In this study, the anti-bacterial activity of the methanol extract against Streptococcus mutans was evaluated. Microdilution was used to determine the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC). The MIC result of methanol extract was found to be-1.48 CFU/ml colonies, at concentration of 0.05%. Meanwhile the MBC result of methanol extract at concentration of 50% no colonies was grows. Based on the results, it can be concluded that methanol extract has a high inhibition activity with 0.05% KHM and 50% KBM concentrations.

Keywords

Inhibition Activity, Methanol Extracts, Laban Leaf, Sreptococcus Mutans, Microdilution