1Faculty of Pharmacy, Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (deemed to be University), Khandagiri, Bhubaneswar – 751030, India
2Principal, Department of Pharmaceutical Sciences, Dadhichi College of Pharmacy, Cuttack- 754002, India
*Corresponding Author E-mail: sabitribindhani@soa.ac.in
Online published on 18 July, 2020.
For poorly water soluble compounds, formulation development has been a great challenge because of its lower solubility and poor oral absorption. Supersaturable selfemulsifying drug delivery system (SS-SEDDS) has been demonstrated as an most effective approach which improves the thermodynamic stability of a supersaturable formulation by inhibiting their precipitation In vivo and provide significantly higher intraluminal concentration of the drug through achieving supersaturation. Maintenance of supersaturation In vivo and the rate and degree of supersaturation by different precipitation inhibitors are the major challenging attributes for the pharmaceutical scientist. Presently, this review will focus on supersaturating drug delivery system including challenges of supersaturated solution and some measures to overcome these circumstances.
Supersaturated sedds, spring theory, parachute theory, precipitation inhibitors, mechanism of precipitation inhibitions
