A Facile and An Efficient Synthesis of 3, 3-Disubstituted Oxindole Scaffolds and their Cytotoxic Properties

Sasikala Maadwar; Rajitha Galla; K.G Santhosh

Year: 2019
Volume: 12
Issue: 3

A Facile and An Efficient Synthesis of 3, 3-Disubstituted Oxindole Scaffolds and their Cytotoxic Properties

Author:
Sasikala Maadwar^1,2, Rajitha Galla^1,, K.G Santhosh²
Total Page Count: 5
DOI: 10.5958/0974-360X.2019.00179.3
Page Number: 1091 to 1095

¹Institute of Pharmaceutical Technology, Sri Padmavati Mahila Vishwavidhyalayam, Tirupati, India

²Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad, India

*Corresponding Author E-mail: maadwarsasikala@gmail.com

Online published on 18 May, 2019.

Abstract

A facile and an efficient synthesis of 3, 3-disubstituted oxindole derivatives were synthesised by treating isatins with electron rich benzene derivatives at room temperature. The compounds were evaluated for cytotoxic activity against human breast cancer cells (MCF7) and human ovarian carcinoma cells (SKVO3) by using MTT assay. Compounds 5(9.2μM and 9.5μM) and 7(8.0μM and 10.4μM) exhibited relatively higher cytotoxic activity against both MCF7 and SKVO3 cell lines, respectively.

Keywords

Isatins, Methoxy Benzenes, Boron Trifluoride Diethyl Etherate, MCF7 and SKVO3

A Facile and An Efficient Synthesis of 3, 3-Disubstituted Oxindole Scaffolds and their Cytotoxic Properties

Abstract

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