Research Journal of Pharmacy and Technology

Scabies is an infectious disease characterized by itching and different types of skin rash. It can be treated successfully by different regimens of anti scabies topical or systemic treatment.

The study is performed to compare the effectiveness of single with combined topical drugs in scabies treatment.

The current work is comparative controlled clinical trial study conducted in Tikrit city-Iraq from first of January 2016 to the end of December 2017. Cluster sample chosen from (7) camps of internally displaced population, then (195) scabies patients chosen randomly. Patients were classified to (7) groups. Researcher was applied different modalities of treatment used for first 6 groups and placebo for control (7^th group). The data collected and drugs prescribed to patients with instruction. Patients were followed weekly by researcher to assess patient's condition, if they still had scabies criteria after 4 weeks of treatment, the researcher deals with them as treatment failure.

The study included 195 scabies patients, from them 50(25.6%) cases were age group (25-> 35). Abdominal lesion is the more frequent presentation of scabies patients in 48(24.6%) cases. The results showed that, the highest cure rate was 28(93.3%) in group 4 ((Permethrine10%+Sulfur10%), then 27(90%) in group 6 (crotamiton10%+Permethrine10%), followed by 26(86.7%) in group 5 (crotamiton10%+Sulfur10%).

The study concluded that cure rate in combined topical drugs modalities groups was higher than single topical modalities.