1Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Kerbala, Iraq
2Department of Chemistry, College of Sciences, University of Kerbala, Iraq
*Corresponding Author E-mail: huthamabd15@yahoo.com
Online published on 8 August, 2019.
In this article, some new heterocyclic derivatives, for example pyrimidine and pyrazoles were synthesized by reaction vanillin with paracetamol utilizing KOH as a catalyst to synthase 3-(4-hydroxy-3-methoxyphenyl)-N-(4hydroxyphenyl)acrylamide(1). The compound (1) on react with Sodium azide, hydrazine, urea, and thiourea in the existence of acetic acid or KOH and ethanol as a catalyst to give (2, 3, 4, 5) compounds. The reaction monitors by TLC. All synthesized compounds have been distinguished by melting point, IR, 1H.NMR spectroscopy.
Vanillin, paracetamol, heterocyclic
