1Department of Biochemistry, Shrimati Indira Gandhi College, Tiruchirappalli, India
2Cluster for Integrative Physiology and Molecular Medicine (CIPMM), Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, No.3, Jalan Greentown, 30450, Ipoh, Perak, Malaysia
3Biochemistry Department, School of Life Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, India
*Corresponding Author E-mail: Jannathul.firdous@unikl.edu.my
Online published on 8 August, 2019.
In the present study, anticancer and cytotoxicity of Aloe vera ethanolic leaves extract was evaluated as the leaves of A.vera are reported to have great medicinal value with potential therapeutic applications. The anticancer activities of the ethanolic leaves extract of A.vera were investigated using 3-(4, 5-dimethylthiazole-2yl)-2, 5diphenyl tetrazolium bromide assay on three human cancer cell lines HepG2 (liver cancer), HeLa (human cervical carcinoma cell line) and A549 (human lung adenocarcinoma epithelial cell line). In anticancer studies, A.vera ethanolic leaves extract showed potent proliferation inhibitory activity against HepG2, HeLa and A549 cell lines. The results have shown that the A.vera ethanolic leaves extract contain some active ingredients with the potential of being anticancer agents. A.vera ethanolic leaves extract has the potential to fight against cancer cells. Further work should be carried out on the characterization of specific anticancer components of A.vera.
Aloe vera, Cancer cell lines, Lipid peroxidation, MTT assay, Phytochemicals
