Research Journal of Pharmacy and Technology

SCOPUS
  • Year: 2019
  • Volume: 12
  • Issue: 7

In vitro Antihyperglycemic activity of unripe fruits extracts of Artocarpus gomezianus

  • Author:
  • Jennifer Fernandes, Ronald Fernandes, Vijay Kumar M., Rajisha K., Ryna V. Lobo
  • Total Page Count: 3
  • Page Number: 3265 to 3267

Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018

Abstract

Diabetes mellitus is a metabolic disorder which results from defects in insulin secretion. Among the various methods of diabetes management, herbal products are best alternative drug with zero side-effects. The aim of this work was to assess the phytochemicals qualitatively and to evaluate the anti-diabetic activity of unripe fruits extract of Artocarpus gomezianus. The in vitro alpha-amylase and alpha-glucosidase inhibitory studies were performed using different concentration of extract and compared with a standard drug. Our assay result suggests that methanolic extract of Artocarpus gomezianus exhibit dose-dependent increase in percentage inhibitory activity on α-glucosidase enzymes (IC50 is 70.29) and α-amylase (IC50 is 68.75). Acarbose was used as a standard drug.

Keywords

in vitro antidiabetic, Artocarpus gomezianus, α-glucosidase, α-amylase enzymes