1Department of Pharmaceutics, Institute of Pharmacy and Technology, Salipur, Cuttack-754202, Odisha, India
2Department of Pharmaceutics, Nirmala College of Pharmacy, Mangalagiri Mandal, Guntur – 522503, Andhra Pradesh, India
3Department of Pharmacy, College of Health Sciences, Mekelle University-1871, Mekelle, Ethiopia
4Department of Pharmaceutical Technology, Jeypore College of Pharmacy, Rondapalli, Jeypore-764002, Koraput, Odisha, India
The flavonoid compound (Acacetin) isolated from fruits of
The acacetin was administered intravenously and orally in Wistar rats at a dose of 2 and 10 mg/Kg body weight respectively. In a regular interval of specified time, blood samples were collected and bioanalyzed to quantify the drug concentration in the blood sample by using LC-MS. The Cmax, Tmax, T1/2, KE, Ka, and bioavailability (F) of acacetin were determined by mathematically and graphically from plasma concentration-time profile data. Absorption rate constant was determined by the method of residual.
From the i.v. Bolus administration data, acacetin had an area under curve (AUC) is 1.542 μg.h/ml, elimination rate constant (KE) is 0.423 h−1, and half-life (T1/2) is two hour. The oral administration of acacetin showed the peak plasma concentration (Cmax) of 1.668 μg/ml, Tmax is 1 h, AUC is 6.44 μg h/ml, KE is 0.416 h−1, T1/2 is 2 h, absorption rate constant (Ka) is 1.6 h and bioavailability of acacetin was found to be 84%.
From the study it could be concluded that the acacetin possessed relatively greater bioavailability; thus this drug exhibited significant satisfactory pharmacokinetic profile which would be helpful for successful designing of a suitable dosage form formulation.
Flavonoid, Pharmacokinetic, Gmelina arborea, Bioavailability, Acacetin
