Dept. of Pharmaceutics, GRY Institute of Pharmacy, Borawan, Khargone (M.P)
Solubility is a key parameter for oral bioavailability of poorly water soluble drugs. Ramipril is sparingly soluble in water which affects the absorption of drug via GIT, and ultimately makes the drug with low bioavailability. In the present study is solubility enhancement of Ramipril by solid dispersion technique. Solid dispersion of Ramipril is prepared by using two polymers ie: Polyvinyl Pyrrolidone (PVP K30) and Polyethylene Glycol 4000 (PEG 4000) in different ratios (1:1, 1:2, 1:3) using solvent evaporation method. On the basis of % drug content and solubility study S.D.2 and S.D.5 solid dispersion were selected an taken for formulation of fast dissolving tablet of Ramipril. On evaluating various FDTs of Ramipril the best formulation was found to be F6 (1:2 PEG 4000) showed disintegration time was 28 sec. and cumulative percentage drug release 97.68% in 40 min.
Bioavailability, Ramipril, PVP K30, PEG 4000, Solid dispersion
