Design, Molecular Modelling and Synthesis of Antihypertensive Agent

Ketones and alcohols are extremely important industrial and biological chemicals. The interconversion of alcohols and ketones or aldehydes occurs in a number of biochemical pathways. Diphenylmethanol bearing number of biological activity like antihypertensive and antiallergic agents as well as intermediate compound for further synthesis of drugs. For these reasons, they gained much attention as important pharmacophore and privileged structure in medicinal chemistry. The objective of this study was to determine efficiency or binding energy of Diphenyl methanol to identify antihypertensive activity. We have reduced alcohol into ketones and performed Molecular modeling. Scoring Function analysis has permitted identification and Characterization of ligand receptor interactions.