Research Journal of Pharmacy and Technology

The present study deals with the synthesis of series of aryl amines based 4-thiazolidinone and 2-azetidinone derivatives from Schiff bases obtained from the condensation of 2-chloro-3-formylquinoline and 2-(4aminophenyl) benzimidazole. The newly synthesized compounds are illustrated in scheme. Schiff bases of aryl amines based 4-thiazolidinone and 2-azetidinone derivatives have been prepared by the reaction of various substituted Schiff base with thioglycholic acid and chloroacetyl chloride respectively. The intermediate Schiff bases were synthesized by the condensation of different quinoline aldehydes with aminophenyl benzimidazole. The starting compound i.e aldehyde was synthesized through Vilsmeier reaction from respective acetanilides. The synthesized compounds were characterized by their physical and spectral data, and were screened for their antibacterial and antifungal activities by using cup plate method against Bacillus subtilis, Bacilus pumilus, Escherichia coli and Pseudomonas aeruginosa, 50, 100 μg/ml concentration using ciprofloxacin as reference standard drug and Aspergillus niger, Candida albicans as same concentration using clotrimazole as reference drug respectively.