Design Synthesis and Evaluation of Anticancer Pyrazole Derivatives of Chalcone Scaffold

Pyrazoles are also a class of compounds that have the ring C3N2 with adjacent nitrogen atoms.^[2] Notable drugs containing a pyrazole ring are celecoxib (Celebrex) and the anabolic steroid stanozolol. Chalcone is an aromatic ketone and an enone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones or chalconoids. Chalcones (1, 3-diaryl propenones), a family of small molecules that are naturally abundant in edible plants, have been found to have antitumor properties for specific cancer cell lines and to interfere in each step of carcinogenesis, including apoptosis.