Formulation development and in-vitro evaluation of potassium chloride extended-release tablets

Potassium chloride tablets help to treat hypokalemia.it is an extended-release tablet, Ethocel 100FP and hydrogenated vegetable oil helps for controlled release. Extended-release reduces gastric irritation.it is soluble in glycerol, so we use isopropyl alcohol as a solvent, direct compression we don’t need any solvent for wet granulation, so we add isopropyl alcohol. For blend parameter’s we use Hausner's ratio from the seven which one is lowest it should be the good one, healthy dose of potassium for an adult is 50 to 100mEq per day. the assay performed by the method of HPLC (anhydrous basis), totally seven formulations was done by direct compression. Wet granulation method, F1 and F2 formulated by direct compression method, F3 formulated by non-aqueous method, F4 to F7 was formulated by wet granulation finally carry out stability study to known the stable formulation. One stability study maintain these following temperature and humidity 40°C±2°C 75% RH ± 5% it is followed by as per the ICH guidelines no changes added in these process, we perform stability test for every month and the data should contain assay, dissolution at 2hrs, and Karl fisher range to known water content. dissolution profile state that drug release with the specific time intervals the value should be close to the reference product (Mfg by Upsher-Smith laboratories inc).