1Department of Chemistry, Kakatiya University, Warangal, India - 506009
2Department of Chemistry, Mahatma Gandhi Institute of Technology, Hyderabad, India - 500075
3Department of Biochemistry, Mahatma Gandhi University, Nalgonda, India, 508254
4Department of Chemistry, Chaitanya Bharathi Institute of Technology, Hyderabad, India, 500075
*Corresponding Author E-mail: gbrahmeshwari@gmail.com
Online published on 28 October, 2020.
A series of new triazinane-2-thiones and imino thiazolidinone-4-ones were synthesized from 2-acetyl benzimidazole (1). Treatment of compound 1 with urea in the presence of I2 furnishes compound (2), which on reaction with Aryl isothiocyanateaffords the compound (3), which undergoes Cyclic condensation of classical Mannich amino methylation of compound 3with formaldehyde and methyl amine produces corresponding triazinane -2-thiones (4), whereas cyclic condensation of compound 3 with cholroacetic acid to furnish the corresponding iminothiazolidinones-4-ones(5).the chemical structures of the newly synthesized compounds have been characterized on the basis of spectral (IR, 1HNMR and Mass) and analytical data. The title compounds were evaluated for their anti-inflammatory activity and molecular docking studies. The docking studies are supporting anti-inflammatory activity exhibiting high inhibition constant and binding energy.
Benzimidazole, Triazinanes and iminothiazolidinones, Antiinflammatory activity and Molecular docking
